Colorado vs. Nebraska prediction, odds: 2024 college football expert picks, Deion Sanders bets

Deion Sanders and the Colorado Buffaloes (1-0) hit the road in Week 2 to take on longtime rival Nebraska (1-0) on Saturday in Lincoln, Nebraska. The Buffs won their season opener, defeating FCS powerhouse North Dakota State 31-26 behind stellar performances from Heisman Trophy candidates Shedeur Sanders and Travis Hunter. The Huskers opened Year 2 of the Matt Rhule era with a dominant 40-7 win over UTEP. Heralded freshman quarterback Dylan Raiola was sharp in his collegiate debut for Nebraska. This will be the 73rd all-time meeting between CU and Nebraska, with the Huskers holding a 49-21-2 series edge.

Kickoff is at 7:30 p.m. ET from Memorial Stadium in Lincoln, Nebraska. The Huskers are 6.5-point favorites in the latest Colorado vs. Nebraska odds, per SportsLine consensus. The over/under for total points is 55.5. Before making any Nebraska vs. Colorado picks, you need to see the Week 2 college football predictions and betting advice from SportsLine’s Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.

Now, Kaylor has dialed in on Colorado vs. Nebraska on Saturday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines on the spread, money line, and over/under for Nebraska vs. Colorado:

• Colorado vs. Nebraska spread: Nebraska -6.5
• Colorado vs. Nebraska over/under: 55.5 points 
• Colorado vs. Nebraska money line: Nebraska -242, Colorado +195
• Colorado vs. Nebraska picks: See picks at SportsLine

Why Colorado can cover

Dylan Raiola may prove to be the savior of Nebraska football, but Colorado has an undeniable edge at the quarterback position in senior Shedeur Sanders. The 6-foot-2, 215-pound Sanders threw for 445 yards and four touchdowns in CU’s season opening win. Sanders led Colorado to a 36-14 win over Nebraska in 2023.

Colorado also has a group of wide receivers that will be a tough test for Nebraska’s secondary. Two-way star Travis Hunter put forth a Heisman Trophy-caliber performance against North Dakota State, catching seven passes for 132 yards and three touchdowns, while also recording three tackles on defense. Jimmy Horn Jr., Will Sheppard and LaJohntay Wester round out the Buffs’ receiving corps. Horn caught seven passes for 198 yards and a touchdown against NDSU. See which team to pick here.

Why Nebraska can cover

Nebraska has a noticeable advantage on the line of scrimmage in this matchup. Colorado has an all-new starting offensive line, and the Huskers have experience in their defensive front seven. If Nebraska can get a consistent pass rush on Sanders, it can help neutralize Colorado’s speed at the wide receiver position. 

Colorado’s defense struggled mightily for most of the game against North Dakota State. Nebraska rushed for 223 yards against UTEP, and the Buffs had issues stopping the run in their season opener. Freshman quarterback Dylan Raiola looked poised in his first collegiate start and his throwing ability will put a lot of pressure on Colorado’s secondary. See which team to pick here.

How to make Nebraska vs. Colorado picks

Kaylor has analyzed Colorado vs. Nebraska from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

So who wins Colorado vs. Nebraska on Saturday in Lincoln, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.